Stability of liposome structure studied by atomic force microscope and a soft sphere model analysis
ZHAO Yan, SUN Run-guang*, ZHANG Xiao-fei
(College of Physics and Information Technology, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)
Abstract:
The particle size, adhesion and rigidity of liposome obtained with hand-shaking method and ultrasonic-filming method were studied by atomic force microscope (AFM). The liposome has a larger particle size with adhesion tendency and weak rigidity compared with that of the liposome obtained by ultrasonic-filming method. According to characteristics of liposome, a soft sphere model was established and the adhesion and rigidity were analyzed theoretically.The results were consistent with that of the experimental observations. This proves that the liposome can be studied as a soft sphere model, and this model provides a quantitative evaluation criterion for the structural stability of the liposome.
KeyWords:
atomic force microscope; liposome; rigidity; soft sphere model
