Abstract:
The open field was used to observe behavioral changes, and the place navigation and the spatial probe in Morris water maze were performed to determine learning-memory abilities.The results showed that,compared with the control group,CRS on both female Microtus mandarinus and ICR mice showed a significant reduction in body weights and decreased the locomotion,rearing and grooming in open field test (P＜001). Compared with the CRS group, hyodermic injection of β-estradiol 3-benzoate(EB) into the animal receiving CRS-treated significantly increased body weight(P＜005)and insignificantly increased behavioral ability, which included locomotion,rearing and grooming in open field test. Compared with the control, CRS on ICR-mice distinctly shortened the latency in place navigation test, while hyodermic injection of EB showed insignificant changes. As to the Microtus mandarinus in Morris water maze, compared with the control, CRS prolonged the latency markedly, but the combination of the injection of EB and the CRS obviously cut down the latency, and improved the times of crossing the exact position of the former platform and the time ratio of remaining in the former platform when compared with the control group and the CRS group. These results suggest that the learning-memory ability of Microtus mandarinus is reduced with CRS, but promotion on ICR mice. Estrogen can improve the stress on good behavior in ICR mice and the impact on learning and memory in Microtus mandarinus.
