Abstract:
To investigate the protective effects of SMND-309 on CCl4 induced hepatotoxicity in mice and the possible mechanisms involved in the protection, male Kunming strain mice were randomly divided into five groups with each consisting of 10 mice. SMND-309 in saline was administered intraperitoneally (ip) at 5, 15 , 25 mg/kg once daily for 7 consecutive days, and then actue liver injury model was induced by 0. 1% CCl4 ip 20 mg/kg. After 24 h, mice were killed to measure serum ALT, AST, ALP and TBIL, and the content of MDA, GSH and antioxidant enzymes in liver and to observe the pathological changes of the liver, the results indicated that pretreatment with SMND-309 could significantly reduce the levels of serum ALT, AST, ALP and TBIL, MDA, and increase activity of GSH and antioxidant enzymes. Liver histopathology also showed that SMND-309 could significantly reduce the incidence of liver lesions induced by CCl4. These results suggest that SMND-309 had inhibitory effects on liver injury in mice induced by CCl4, and the hepatoprotective effects of SMND-309 may be due to its antioxidant property.
