LI Jiao-yi1, LIU Xiao-li1, ZHANG Xi-quan2, GU Hong-mei2, WANG Fan1, WANG Xiao-mei1, LI Bao-lin1*
(1 Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Chemistry and Materials Science, Shaanxi Normal University, Xi′an 710062, Shaanxi, China; 2 Jiangsu Chia Tai Tianqing Pharmaceutical Co. Ltd., Nanjing 210042, Jiangsu, China)
Abstract:
Six novel 4-arylamino-6-fluoroquinazolines such as 4-[4-((E)-3,4,5-trimethoxystyryl)]anilino-6-fluoroquinazoline etc. were synthesized from 6-fluoro-4-chloroquinazoline and trans-aminostilbene derivatives in yields of 55%~76%. Their chemical structures were identified by 1H NMR, IR and elemental analysis. The 1H NMR analysis showed that the single peak in the δ 9.74~9.79 ppm was produced by the—NH of the 4-position in the compounds; The IR analysis showed that the peak in 3 618~3 278 cm-1 also proved the formation of the target compounds.
KeyWords:
quinazoline derivatives; stilbene derivatives; synthesis
