Abstract:
The lipid components extracted from brewer′s yeast were analyzed by GC-MS. The hypolipidemic assistant function of the yeast lipid in soft capsules was evaluated by observing the level of TC, TG and HDL-C in blood of hyperlipoidemia Wistar rats influenced by the yeast lipid. The hyperlipoidemia model rats were established by feeding high cholesterol feeds. The test preparation were intragastrically administrated to the rats with the dose of 0.15 g/kg bw, 0.30 g/kg bw and 0.90 g/kg bw respectively once a day, and continued for 35 days. The administrated volume of test preparation was 0.5 mL/100g bw. The hyperlipoidemia control groups were intragastric administrated by the same volume of edible peanut oil. The blood samples from the tail of rats were used for measuring indexes of blood cholesterol. The results of GC-MS analysis showed that the main component is polyunsaturated aliphatic alkene, and the content is 37.74%,28.30%,26.63% respectively in three different samples; The second component is unsaturated fatty acid, and the content is 27.83%,23.42%,30.75% respectively. The results of functional experiments indicated that the blood TC levels of low-dosage group, middle-dosage group and high-dosage group with yeast lipid soft capsules were decreased 8.33%, 14.49% and15.94% respectively, the blood TG levels were decreased 10.80%, 17.07% and 18.47% respectively, and the blood HDL-C levels were increased 0.05 mmol/L, 0.06 mmol/L and 0.07 mmol/L respectively compared with the control group. These results indicated that the yeast lipid soft capsule has the hypolipidemic assistant function.
