TritonX-100在磷脂酰丝氨酸-胆固醇分子层的嵌入量的计算与分析-陕西师范大学学报期刊社网站

陕西师范大学学报（自然科学版）

物理学

TritonX-100在磷脂酰丝氨酸-胆固醇分子层的嵌入量的计算与分析

张明1，张敏妍2，孙润广3

(1 西安理工大学理学院，陕西西安 710054； 2 第四军医大学数理教研室，陕西西安 710032；3 陕西师范大学物理学与信息技术学院生物物理与生物医学工程实验室，陕西西安 710062)

张明,男,助教,研究方向为分子生物物理.E-mail: zmlxy@xaut.edu.cn.

摘要:

运用热力学吉布斯吸附方程和表面张力公式,计算了不同膜压下磷脂酰丝氨酸-胆固醇形成分子层中非离子去污剂Triton X-100嵌入量、Triton X-100“过剩量”以及体系中对应的自由能的变化.结果表明:随着膜压的不断增大,磷脂酰丝氨酸-胆固醇分子层中Triton X-100的嵌入量逐渐增大.单位面积内Triton X-100“过剩量”和体系自由能变化量均与分子层膜压成正比.

关键词：

吉布斯吸附方程；嵌入量；非离子去污剂

收稿日期：

2010-09-15

中图分类号：

Q613； Q68

文献标识码：

文章编号：

1672-4291(2011)02-0038-03

基金项目：

国家自然科学基金资助项目(20772077) .

Doi:

Calculation and analysis about the insertion of Triton X-100 in phosphatidyle thanolamine/cholesterol Bilayer

ZHANG Ming1, ZHANG Min-yan2, SUN Run-guang3

(1 College of Sciences, Xi′an University of Technology, Xi′an 710054, Shaanxi, China；2 Department of Mathematics and Physics, the Fourth Military Medical University, Xi′an 710032, Shaanxi, China；3 Laboratory of Biophysics and Biomedicine Engineering, College of Physics and Information Technology, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)

Abstract:

The insertion of non-ionic detergent Triton X-100 in the Phosphatidyle thanolamine/cholesterol bilayer has been studied by the Gibbs adsorption equation and surface tension equation. The equations are deduced to give out the “excess” molar amounts of Triton X-100 and the variation of free energy in the system. The results showed that the insertion molar amounts and the “excess” molar amounts of Triton X-100 is increased as the surface pressure increase. The variation of free energy is in proportion to the surface pressure of bilayer.

KeyWords:

Gibbs adsorption equation; insertion molar amounts; non-ionic detergent