不同取代度羟丙基-β-环糊精与法莫替丁包合作用研究-陕西师范大学学报期刊社网站

陕西师范大学学报（自然科学版）

化学与材料科学

不同取代度羟丙基-β-环糊精与法莫替丁包合作用研究

毛宇鸿，张朋利，王利平，王伟*，李宝林

(陕西师范大学化学与材料科学学院，陕西西安 710062)

毛宇鸿,女,硕士研究生,主要研究方向为药物化学. E-mail: maoyuhong@163.com.* 通信作者：王伟,女,副教授,博士. E-mail: wwlzz@snnu.edu.cn.

摘要:

采用溶液搅拌法制备了5种不同取代度（SD）的羟丙基-β-环糊精（HP-β-CD）与法莫替丁的包合物，并通过红外光谱法（IR），X射线衍射法（XRD），紫外光谱法（UV）等对其进行了包合鉴定．采用相溶解度法计算了5种HP-β-CD/法莫替丁包合物的表观平衡常数（Kc），研究了不同取代度的羟丙基-β-环糊精与法莫替丁的包合作用．结果表明，不同取代度的HP-β-CD对法莫替丁均产生了包合作用，且SD=6.2的HP-β-CD/法莫替丁包合物表观平衡常数最大（Kc=749 M-1），达到了最佳的包合效果．

关键词：

法莫替丁；羟丙基-β-环糊精；包合物

收稿日期：

2010-05-15

中图分类号：

O621.4； R283.1

文献标识码：

文章编号：

1672-4291(2011)03-0048-03

基金项目：

中央高校基本科研业务费专项资金项目(GK200902041)

Doi:

Study on inclusion of famotidine by hydroxy propyl-β-cyclodextrin with different substitution degree

MAO Yu-hong, ZHANG Peng-li, WANG Li-ping, WANG Wei*, LI Bao-lin

(College of Chemistry and Materials Science, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)

Abstract:

Five inclusion complexes between famotidine and hydroxy propyl-β-cyclodextrin (HP-β-CD) with different substitution degree were prepared. The complexes were characterized by infrared spectroscopy (IR), powder X-ray diffraction (XRD) and ultra-violet spectroscopy (UV). The apparent equilibrium constants (Kc) of the five inclusion complexes were determined by using phase-solubility method; The effects of the substitution degrees of HP-β-CD on formation of the inclusion complex of HP-β-CD/famotidine were investigated. The results showed that the inclusion complexes could produced for HP-β-CD with different substitution degree and the best inclusion formed at SD(substitution degree)=6.2. The solubility of famotidine were greatly improved by HP-β-CD with SD=6.2．

KeyWords:

famotidine; hydroxypropyl-β-cyclodextrin; inclusion complexes