WU Di, PAN Xin, Zhang Dong-mei, CHEN Ya-shao*
( Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education; College of Chemistry and Materials Science, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)
Abstract:
Poly (lactide-co-glycolide) (PLGA) is a biocompatible and degradable polymer, and it is widely used in the field of medicine. Using lactic acid and glycolic acid, poly(lactide-co-glycolide) (PLGA) was synthesized by ring-opening melting polymerization in condition of microwave irradiation. The molecular weight, molecular structure and performance of the prepared polymer were characterized by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and contact angle (CA). Furthermore, effect of monomer rate on the properties of PLGA copolymer was investigated. The results show that molecular weight of the PLGA increases with increase of lactic acid, while the corresponding Tg decreases.
KeyWords:
microwave irradiation; melting polymerization; poly(lactide-co-glycolide)
