Investigation on the chemiluminescence system of luminol-Cu(Ⅱ)-metformin hydrochloride
LI Hong1,2, DU Jian-xiu1,*
(1 College of Chemistry and Materials Science, Shaanxi Normal University, Xi′an 710062, Shaanxi, China; 2 Weinan Vocational Technical College, Weinan 714000, Shaanxi, China)
Abstract:
A new chemiluminescence system, luminol-Cu(Ⅱ)-metformin hydrochloride system, was investigated for the determination of metformin hydrochloride. The experimental conditions were carefully optimized. Under the optimum conditions, the concentration of metformin hydrochloride related to the chemiluminescence intensity was linear in the range of 1.0×10-9～1.0×10-7 g/mL. The detection limit of the method was 5×10-10 g/mL. The relative standard deviation was 1.1% for the 11 replicated determinations of 1.0×10-8 g/mL metformin hydrochloride. The proposed method was applied to the determination of metformin hydrochloride in tablets.
KeyWords:
metformin hydrochloride; chemiluminescence; flow injection; luminol; Cu(Ⅱ)
