自然科学版
陕西师范大学学报(自然科学版)
体育科学
运动训练长期停训对大鼠胸腺组织细胞凋亡的影响
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朱德元1,2,田振军2
(1 宝鸡文理学院 体育系,陕西 宝鸡 721013; 2 陕西师范大学 体育学院,西安 710062)
朱德元,男,讲师,硕士研究生,研究方向为运动与免疫功能.
摘要:
采用免疫组织化学方法,分析运动训练长期停训后大鼠胸腺指数和胸腺组织细胞凋亡蛋白Bax和Bcl-2的表达,探讨运动训练长期停训对胸腺组织细胞凋亡的影响.结果表明,不同强度运动长期停训后,Bax和Bcl-2阳性表达主要位于胸腺皮质区淋巴细胞胞浆,髓质区表达不明显,有氧运动组与安静对照组比较无显著性差异(P>0.05),胸腺指数变化虽有增加但无显著性差异,表明运动训练产生的生物学效应在长期停止训练后消失;疲劳运动组与安静对照组和有氧运动组比较,Bax和Bcl-2阳性表达均差异显著(P<0.05),胸腺指数显著性降低(P<0.05),表明大强度疲劳训练产生的生物学效应在长期停止训练后,伴随着胸腺器官的增龄性变化而下降.推测可能是大强度长期训练引起机体晚年不适的原因之一.
关键词:
胸腺; 长期停训; 细胞凋亡; 大鼠
收稿日期:
2009-04-10
中图分类号:
G804.5
文献标识码:
A
文章编号:
1672-4291(2009)06-0102-04
基金项目:
陕西省自然科学基金资助项目(2004C232); 宝鸡文理学院重点科研基金资助项目(ZK06126)
Doi:
Effects of exercises training on thymic tissue's apoptosis of rats after long-term stop trained
ZHU De-yuan1, TIAN Zhen-jun2 *
(1 Department of Physical Education,Baoji University of Arts and Sciences, Baoji 721013, Shaanxi China; 2 College of Physical Education, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)
Abstract:
Using immunohistochemical method,to investigate the long-term exercise training after the training stopped thymus apoptosis.The resulta show that different intensity exercise training after long-term suspension, Bax and Bcl-2 expression, mainly in the cytoplasm of lymphocytes in thymus cortex and medulla expression was not obvious, aerobic exercise group compared with the quiet control group, no significant difference (P>0.05),although the increase in thymus index but no significant difference, indicating that exercise training produced long-term biological effects disappear aftercessation of training; fatigue exercise group with the quiet control group and aerobic exercise group,Bax and Bcl-2 positive expression were significantly different (P
KeyWords:
thymic; Long-term stop training; apoptosis; rat