Abstract:
To study the effect of ebselen on the contents of MDA、 SOD and GSH-Px, total antioxidant capacity, and the expression of NO and NOS system in the trained-indurance rat brain tissue, thirty healthy male SD rats were randomized into 3 groups, namely, the control group(A), exercise group(B) and exercise added ebselen group(C) with 10 rats in each group. The high-intensity and endurance-trained model is established with the last groups for 8 weeks and the contents of MDA、 SOD、 GSH-Px、 TAOC、 NOS、 iNOS and NO were tested in rat brain tissue. Compared with control group, all above mentioned parameters mentioned above in exercise group have notable changes;After being interfered with ebselen, there are significantly improvement in the various index compared with exercise group. This result indicates that high-intensity and endurance-trained can decrease the antioxidase′s activity in rat′s brain and this decrease can be weakened through supplementing ebselen. Ebselen has significant protective effect on brain tissue of exercise training injury.
