流动注射化学发光法测定血浆和尿液中的酒石酸美托洛尔-陕西师范大学学报期刊社网站

陕西师范大学学报（自然科学版）

化学与材料科学

流动注射化学发光法测定血浆和尿液中的酒石酸美托洛尔

李冬冬，杜建修*，吕九如

(陕西师范大学化学与材料科学学院，陕西西安 710062)

李冬冬，女，硕士研究生，主要从事化学发光方面的研究．

摘要:

酒石酸美托洛尔与Eu3+形成的配合物对KMnO4-Na2SO3化学发光反应具有强的增敏作用，据此建立了测定酒石酸美托洛尔的流动注射化学发光新方法．该方法测定酒石酸美托洛尔的线性范围为50×10-7～10×10-5g/mL，检出限为1×10-7g/mL．对浓度为10×10-6g/mL酒石酸美托洛尔溶液连续11次平行测定的相对标准偏差为14%．该方法已用于血浆和尿液中酒石酸美托洛尔含量的测定．

关键词：

酒石酸美托洛尔;化学发光;流动注射;Eu3+

收稿日期：

2007-11-25

中图分类号：

O657.3

文献标识码：

文章编号：

1672-4291(2008)06-0063-03

基金项目：

陕西师范大学青年基金资助项目

Doi:

Determination of metoprolol tartrate in human plasma and urine by flow injection chemiluminescence

LI Dong-dong, DU Jian-xiu*, Lü Jiu-ru

(College of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, Shaanxi, China)

Abstract:

In this work, it was found that the weak signal from KMnO4-Na2SO3 reaction was greatly enhanced by Eu3+-metoprolol tartrate complex. Basted on this fact, a new flow injection chemiluminescence method for the determination of metoprolol tartrate was proposed. The linear range and detection limit for determination of metoprololtartrate are 50×10-7～10×10-5and 1×10-7g/mL, respectively. The relative standard deviation is 14%(n=11) for a level of 10×10-6g/mL metoprolol tartrate. This method was applied to the determination of metoprolol tartrate in human plasma and urine samples.

KeyWords:

metoprolol tartrate; chemiluminescence; flow injection; europium