Abstract:
A novel method for the synthesis of nerolin Ⅱ from the reaction between bromethane and β-naphthol in presence of phase transfer catalyst, polyethylene glycol (PEG—600), is described in this report. The effects of reaction conditions, including temperature, catalyst concentration, ratio of reactants, and reaction time, on the yield of product were systematically investigated. The product yield being 67.0% was achieved under the optimal conditions established in this study. The optimal conditions are obtained by experiment, the molar ratio of transfer catalyst to substrate β-naphthol being 5%, the molar ratio of β-naphthol to bromethane 0.83, temperature 70℃ and reaction time 5h.
