Abstract:
In order to investigate the changes of gastric mobility in chronic unpredicted mild stress (CUMS ), and the effect of 5-HT microinjection into amygdaloid nucleus on the changes of gastric mobility induced by CUMS , the depression model of rats established by CUMS was used. By observing the behavior of open field-test, sucrose preference-test, forced swimming- test and the changes in body weight ,and then examining the effects of intra-amygdaloid injection of 5-HT on the gastric mobility, some information has been obtained. The results show that the percentage of sucrose preference, the scores of locomotion ,rearing, grooming in CUMS group extremely reduced and the body weight gain was negative； the intragastric pressure and gastric motility markedly decreased；intra-amygdaloid injection of 5-HT could markedly improve the gastric mobility reduced by CUMS, which could be affected by the 5-HT1A receptor antagonist spiperone；the improvement of the gastric mobility induced by intra-amygdaloid injection of 5-HT was eliminated when vagotomy was severed. These results suggest that CUMS can actually reduce the gastric mobility. Intra-amygdaloid injection of 5-HT can improve the gastric mobility of CUMS treated-rats, which can be partly attributed to mediation of receptor antagonist spiperone and transmittance by vagus.
