Ningnanmycin is a pollution-free bioticpesticede which has characteristics of extensive applications, high efficiency, harmfulness, and low remainder. It is evolved from Strepcomdes noursei var. xichangensis. Traditionally, the heat treatment under the high-temperature is used to kill germ of the Ningnanmycin ferment liquid. In this work, the industrial producting for germ-killing by the acidizing treatment of the Ningnanmycin ferment liquid is reported. The concentrated sulfuric acid are selected to kill the living myceliums. The best acidizing conditions are to be that the pH value is in the range of 2.0～2.5 and the acidizing time is 60 min. The results indicate that the acidizing method for killing myceliums doesn′t affect the biological efficacy and the stability of Ningnanmycin compared with the heat treatment. This method could shorten the producting period, improve the producting efficiency, and lower the cost of products.

acidizing； ningnanmycin； killing mycelium； industrialization