Study on adsorption and release of salicylic acid by cross-linking chitosan resin with the template-occupying
MENG Xiao-rong1, ZHANG Min1,2, LI Kai1, YANG Xiao-guang1
(1 College of Natural Science， Xi′an University of Architecture and Technology, Xi′an 710055, Shaanxi, China; 2 College of Chemistry and Chemical Engineering, University of Shaanxi Science and Technology, Xianyang 712081, Shaanxi, China)
Abstract:
Template-occupying protected-chitosan resin (PT-CTS) was prepared to protect the amino group by forming Schiff base between benzaldehyde and chitosan, and using epichlorohydrin as cross-linking agent. For comparision, the cross-linked unprotected-chitosan (UNPT-CTS) and porous acetylated-chitosan (P-CT) were prepared by means of freeze-drying under heterogeneous condition. The structure and granularity of resin characterized by FTIR and AFM, and salicylic acid adsorption to the three resins and the sustained release behavior under different pH were studied. Physicochemical principle for the absorption was proposed. The results indicate that PT-CTS had the higher adsorption quantity and initial adsorption ability in comparison with UNPT-CTS and P-CT, the sustained release behavior of PT-CTS exhibited a steady ability and a strong dependence on the acidity in the medium. PT-CTS could be used as a potential slow-released agent to the intestinal canal.
KeyWords:
chitosan; resin; absorption; release
