硫化镉纳米粒子荧光淬灭测定柳氮磺吡啶-陕西师范大学学报期刊社网站

陕西师范大学学报（自然科学版）

专题研究

硫化镉纳米粒子荧光淬灭测定柳氮磺吡啶

张犁黎，郑行望，屈颖娟，刘环宇

(陕西师范大学化学与材料科学学院，陕西西安 710062)

张犁黎，女，硕士研究生，主要从事化学发光分析方面的研究工作．

摘要:

以硫代乙酰胺(TAA)与Cd2+在碱性溶液中反应制备了CdS荧光纳米粒子，该纳米粒子的荧光强度强烈的被药物成分柳氮磺吡啶所淬灭，建立了一种高选择性的测定柳氮磺吡啶的荧光分析新方法．结果表明，在pH值为11-2时，对于柳氮磺吡啶的检测下限可达到1×10-7 g/mL，线性范围为5-0×10-7 g/mL～1-0×10-4 g/mL．方法已用于药片中柳氮磺吡啶的测定．

关键词：

硫化镉纳米粒子;硫代乙酰胺;荧光淬灭;柳氮磺吡啶

收稿日期：

2005-12-29

中图分类号：

O657.3

文献标识码：

文章编号：

1672-4291(2006)02-0074-03

基金项目：

国家自然科学基金资助项目（20575040）

Doi:

A method for determination of sulfasalazine based on fluorescence quenching of CdS nanoparticles

ZHANG Li-li, ZHENG Xing-wang, QU Ying-juan, LIU Huan-yu

(College of Chemistry and Materials Science, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)

Abstract:

CdS nanoparticle was synthesized by reaction of Cd2+ and TAA (thiacetamide) in alkaline medium. Based on the fluorescence intensity of CdS nanoparticle weakened by sulfasalazine, a highly selective fluorescence method for sulfasalazine has been developed. The result showed that the detection limit was 1×10-7 g/mL and the linear ranged from 5-0×10-7～1-0×10-4 g/mL when the pH was in 11-2. This method has been successfully applied to analyzing of sulfasalazine in tables.

KeyWords:

CdS nanoparticle; thiacetamide; fluorescence quenching; sulfasalazine