Abstract:
Pancreatic cancer is a highly aggressive malignancy with a low survival rate. The high degree of interstitial fibrosis in the tumor microenvironment of pancreatic cancer plays an important role in the occurrence and development of pancreatic cancer, and seriously affects the therapeutic effects of pancreatic tumors. In recent years, reversing the tumor microenvironment of pancreatic cancer fibrosis has become a new strategy in the treatment of pancreatic cancer. On these basis, this article summarizes the latest research progress in inhibiting fibrosis treatment of pancreatic cancer from three perspectives, including the targeted mesenchymal cells treatment (pancreatic stellate cells and related fibroblasts), the targeted stromal elements treatment (collagen and hyaluronic acid) and the targeted fibrosis mechanism treatment (epithelial-mesenchymal transformation, hedgehog signaling pathways and wound healing). The construction of cell and animal fibrosis models in current anti-fibrosis research is also introduced，so as to provide references for the tumor microenvironment treatment of pancreatic cancer.
