Abstract:
Parkison′s disease (PD) is a common degenerative disease of the nervous system. Its pathogenesis is complex and unclear, and it is still difficult to cure through traditional drugs and surgical methods. In addition, due to the existence of the blood-brain barrier(BBB), most therapeutic drugs are difficult to enter the lesions in the brain, which seriously weakened the clinical treatment effect of PD. In recent years, it has been found that ultrasound not only plays an important role in non-invasive neural regulation, but also can be combined with microbubbles to reversibly open the BBB, mediate the local delivery of drugs or genes to improve the utilization rates of therapeutic drugs in the brain. Based on the introduction of PD pathogenesis and its traditional treatment methods, this paper reviews the recent advances in ultrasound-mediated PD therapy, including the application potential of ultrasound in opening blood-brain barrier during PD treatment, the direct use of ultrasound in PD treatment, as well as the application of ultrasound mediated drug delivery/gene delivery/carrier delivery systems in PD treatment. Finally, the research direction of ultrasound in PD treatment in the future is proposed, so as to provide ideas for the development of new clinical effective treatment approaches of PD.
