Abstract:
Based on the previous study of synthesis and function research of body protection compound 157 (BPC157), a candidate drug for wound and fracture healing, the effects of intramuscular injected BPC157 on mice central nervous system, beagle cardiovascular and respiratory systems were explored. It was found that the administration of BPC157 had no significant influence on the autonomic activity and motor coordination ability of mice, demonstrated no synergistic effect with the subthreshold hypnotic dose of pentobarbital sodium. BPC157 injection also did not affect the heart rate and blood pressure of anesthetized beagles, showed no significant prolongation for TH, ST, QRS, PR, QT and QTc in ECG, and did not change the respiratory rate and respiratory amplitude of beagles. Our finding indicated that BPC157 had no significant effect on the central nervous system, respiratory system and cardiovascular system function of the studied animals, which ensured the safety for the further clinical application of BPC157.
