自然科学版
陕西师范大学学报(自然科学版)
功能化合物及其生物活性研究专题
两种新型苯甲酰腙配合物的合成及其结构和抑菌活性研究
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高霞1, 2*,乔成芳1*,刘永亮1,周春生1,张国春1
(1 商洛学院 化学工程与现代材料学院,陕西省尾矿资源综合利用重点实验室,陕西 商洛 726000;2 陕西师范大学 化学化工学院,陕西省大分子科学重点实验室,陕西 西安 710119)
高霞,女,讲师,博士,研究方向为金属有机骨架材料及其催化性能。 E-mail: xiagao2007@163.com 乔成芳,女,副教授,研究方向为金属有机骨架材料及其催化性能。 E-mail: xiaoqiaocf@126.com
摘要:
在无水乙醇中以丙酮酸和3-甲氧基苯甲酰肼为原料,通过缩合反应合成丙酮酸-3-甲氧基苯甲酰腙(PMBH)。以自制PMBH为配体,使用传统溶液法在水-乙醇混合溶剂中分别与稀土金属离子Ho3+和Dy3+自组装,得到两种结构新颖的配合物:\[Ho(PMBH)3\]\[Ho′(PMBH)3\](1,Ho(Ⅲ))和\[Dy(PMBH)3\]\[Dy′(PMBH)3\]·2CH3OH·H2O(2,Dy(Ⅲ))。采用元素分析、X-射线粉末衍射、X-射线单晶衍射、红外光谱、热重分析等手段对配合物1和2的结构和性质进行表征,采用菌落直径法研究了配合物1和2及其自由配体PMBH对腐皮镰刀真菌的抑菌活性。结果表明,配体PMBH及其配合物1和2对腐皮镰刀真菌的生长都具有抑制作用,且配合物1和2对腐皮镰刀真菌的抑制作用较配体PMBH更强。
关键词:
Ho(Ⅲ);Dy(Ⅲ);配合物;丙酮酸-3-甲氧基苯甲酰腙;抑菌活性
收稿日期:
2018-12-15
中图分类号:
O614
文献标识码:
A
文章编号:
1672-4291(2020)05-0011-08
基金项目:
国家自然科学基金(201703135);商洛学院科研基金(19SKY003)
Doi:
Synthesis and antibacterial activities of two novel holmium(Ⅲ) and dysprosium(Ⅲ) complexes with benzoyl hydrazone ligand
GAO Xia1,2*, QIAO Chengfang1*, LIU Yongliang1, ZHOU Chunsheng1,ZHANG Guochun1
(1 Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources, Department of Chemical Engineering and Modern Materials, Shangluo University, Shangluo 726000, Shaanxi, China;2 Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi′an 710119, Shaanxi, China)
Abstract:
A novel hydrazone ligand pyruvate-3-methoxy benzoyl hydrazone (PMBH) has been synthesized from pyruvic acid and 3-methoxybenzhydrazide in anhydrous alcohol. The conventional solution reaction of PMBH with rare earth ions (RE3+=Ho3+ and Dy3+) in water-ethanol solvent was carried out to generate two novel complexes:\[Ho(PMBH)3\]\[Ho′(PMBH)3\] (1)and\[Dy(PMBH)3\]\[Dy′(PMBH)3\]·2CH3OH·H2O(2).The structures and properties of the two complexes were investigated by means of elemental analysis, X-ray powder diffraction (XRPD), X-ray single-crystal diffraction, fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric analysis(TGA). The antibacterial activities of PMBH ligand and its complex 1 and 2 against Fusarium solani were investigated by colony diameter method. The results showed that they all demonstrated antibacterial activities against Fusarium solani, and complex 1 and 2 have much stronger antibacterial activities than that of the PMBH ligand.
KeyWords:
holmium(Ⅲ); dysprosium(Ⅲ); complex; pyruvate-3-methoxy benzoyl hydrazone; antibacterial activity