Localized and controllable rabbit abdominal aorta atherosclerosis (AS) model induced by ultrasound cavitation endothelial injury may overcome the disadvantages of uncontrollable plaque size and site in present existing AS animal model. The cavitation injury degree of rabbit abdominal aorta needs to be evaluated during the modeling process.The phase-change nanodroplets were used as artificial cavitation nucleus to damage the rabbit abdominal aorta endothelium under focused ultrasound exposure, and passive cavitation detect was used to analyze the passive cavitation signal and calculate the inertial cavitation dosage (ICD). Compared with the pathology results of vessel wall damage, it was found that ICD was related with the degree of abdominal aortic injury and can be used as a parameter to indirectly evaluate vascular cavitation injury.

passive cavitation detect; focused ultrasound; cavitation injury; atherosclerosis