自然科学版
陕西师范大学学报(自然科学版)
新型冠状病毒肺炎研究专题
新型冠状病毒肺炎潜在药物和疗法的作用机制及治疗现状
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东静玉,宋佳静,孙燕*,李治*
(陕西师范大学 生命科学学院,陕西 西安 710119)
孙燕,女,副教授,硕士生导师,研究方向为分子微生物学及应用微生物学。E-mail:sunyan@snnu.edu.cn;李治,男,教授,博士生导师,研究方向为分子病毒学。E-mail:lizhi@snnu.edu.cn
摘要:
为了尽快解决新型冠状病毒肺炎(COVID-19)临床无特效药物的现状,“老药新用”成为国内外相关研究机构采取的主要抗疫策略之一。本文在比较COVID-19病原体SARS-CoV-2与SARS-CoV及其他相关RNA病毒的异同点、分析其特点及侵染机制的基础上,对当前已报道的有望治疗COVID-19的潜在药物和治疗方法进行归纳总结,主要包括以病毒为靶点的药物(阿比朵尔、格瑞弗森、利巴韦林、瑞德西韦、法匹拉韦、达芦那韦、克力芝、双硫仑)、以宿主为靶点的药物(干扰素、恢复期血浆制品、氯喹/磷酸氯喹)、机制复杂的中草药以及干细胞疗法和RNAi疗法,重点阐释相关药物及疗法的具体作用机制及其应用于COVID-19的治疗现状,以期为COVID-19有效药物的研发和治疗提供一定的参考。
关键词:
新型冠状病毒肺炎;SARS-CoV-2;药物作用机理;病毒靶点;宿主靶点
收稿日期:
2020-03-30
中图分类号:
R965
文献标识码:
A
文章编号:
1672-4291(2020)03-0007-11
基金项目:
国家自然科学基金(31670163)
Doi:
The action mechanism and treatment status of potential drugs and therapies for coronavirus disease 2019
DONG Jingyu,SONG Jiajing,SUN Yan*,LI Zhi
(School of Life Sciences, Shaanxi Normal University, Xi′an 710119, Shaanxi, China)
Abstract:
With the global prevalence of coronavirus disease 2019 (COVID-19), the development of anti-COVID-19 drugs is becoming more and more urgent. As there are no specific drugs available for COVID-19 currently, “new use of old drugs” has become one of the main anti-epidemic strategies adopted by many research institutions at home and abroad. On the basis of analyzing COVID-19 characteristics, infection mechanism and the similarities of SARS-CoV-2 (the pathogen of COVID-19) with SARS-CoV and other related RNA viruses, the antiviral drugs and therapies which may be useful to treat COVID-19 were analyzed and summarized, including virus-targeted drugs, host-targeted drugs, herbal medicine, stem cell therapy and RNAi therapy. The specific action mechanism of relevant drugs and therapies as well as their current application status in the treatment of COVID-19 were mainly elucidated, so as to provide certain reference for the development of effective drugs and treatment methods for COVID-19.
KeyWords:
COVID-19; SARS-CoV-2; mechanism of drugs; virus targets; host targets