体力活动干预对大学生抑郁症的改善效果与代谢机制-陕西师范大学学报期刊社网站

陕西师范大学学报（自然科学版）

运动生物学专题

体力活动干预对大学生抑郁症的改善效果与代谢机制

姚崇1, 赵闪光2, 毛志宏3, 惠琪1, 强家豪2,马强2, 王保平2, 严军虎4, 池爱平2*

（1 陕西师范大学心理学院， 2 陕西师范大学体育学院，3 陕西师范大学学生处心理咨询中心，4 陕西师范大学学府医院，陕西西安 710119）

池爱平，男，教授，博士，主要从事青少年慢性病与运动改善方面的研究。Email: chimu@snnu.edu.cn

摘要:

为探索不同体力活动水平对大学生抑郁症的改善效果及其代谢机制，本文采用贝克抑郁量表（BDI）和抑郁自评量表（SDS）对抑郁症大学生进行筛选，对其进行18周的体力活动干预。采集实验对象的尿液样本，利用液相质谱（LCMS）法以及MetPA数据库对样本进行差异代谢物检测与代谢通路分析。结果表明：体力活动干预对抑郁症具有显著的改善效果；抑郁症组筛选出15个差异代谢物（4↑11↓），涉及5条代谢通路（辅酶Q生物合成、甘氨酸丝氨酸苏氨酸代谢、酪氨酸代谢、嘧啶代谢和类固醇代谢）紊乱；而高体力活动干预后，筛选出33个差异代谢物（19↑14↓），涉及8条代谢通路（辅酶Q生物合成、酪氨酸代谢、嘧啶代谢、色氨酸代谢、谷氨酸丙氨酸天冬氨酸代谢、组氨酸代谢、精氨酸脯氨酸代谢和谷氨酰胺谷氨酸代谢）的改变。结果说明,长期体力活动对抑郁症的改善机制与辅酶Q生物合成、酪氨酸代谢和嘧啶代谢3条代谢通路相关。

关键词：

抑郁症；体力活动；代谢组学；大学生

收稿日期：

2018-03-12

中图分类号：

G806

文献标识码：

文章编号：

16724291(2019)03002110

基金项目：

国家自然科学基金（31871209）；教育部青年基金(19YJC890053);第62批中国博士后科学基金（2017M623100）

Doi:

The improvement effect and metabolic mechanism of physical activity intervention on depression in college students

YAO Chong1, ZHAO Shanguang2, MAO Zhihong3, HUI Qi1, QIANG Jiahao2,MA Qiang2, WANG Baoping2, YAN Junhu4, CHI Aiping2*

(1 School of Psychology, 2 School of Physical Education,3 Psychological Counseling Center of Student Affairs Office,4 University Hospital, Shaanxi Normal University, Xi′an 710119, Shaanxi, China)

Abstract:

In order to explore the effect of different levels of physical activity on college students′ depression and the corresponding metabolic mechanism, Beck depression inventory (BDI) and selfrating depression scale (SDS) were used to screen out the students with depression. 18 weeks of high physical activity intervention were carried out and urine samples were collected from the subjects.The differential metabolite detection and related metabolic pathway analysis were performed on the samples by liquidphase mass spectrometry (LCMS) and MetPA database. The results showed that physical activity intervention group had a significant improvement on the depressive symptoms.The depression group screened 15 differential metabolites (4↑11↓), involving 5 metabolic pathways (ubiquinone biosynthesis, glycineserinethreonine metabolic, tyrosine metabolism, pyrimidine metabolism and steroid hormone biosynthesis).After intervention with high physical activity, 33 differential metabolites (19↑14↓) were screened, involving 8 metabolic pathways (ubiquinone biosynthesis, tyrosine metabolism, pyrimidine metabolism, tryptophan metabolism, alanineaspartateglutamate metabolism, histidine metabolism, arginineproline metabolism and glutamineglutamate metabolism).The high level of physical activity has a significant improvement on the depressive symptoms of college students.Its metabolic mechanism is related to the improvement of three pathways: ubiquinone biosynthesis, tyrosine metabolism and pyrimidine metabolism under longterm high physical activity intervention.

KeyWords:

depression; physical activity; metabonomics; undergraduate