The aim of present study is to investigate the differences in the regulation of Proto and Arky neurons involved in basal ganglia movement by observing the electrophysiological characteristics of the two subtypes of gammaaminobutyric acid neurons after exerciseinduced fatigue.Healthy male Wistar rats (260~300 g) were randomly divided into control group (CG), 1day fatigue group (1FG), 3day fatigue group (3FG) and 7day fatigue group (7FG). The progressive increasing load treadmill program was used to establish a repetitive exhausted exerciseinduced fatigue model. The spontaneous firing activity of neurons in the external globus pallidus was recorded by the in vivo extracorporeal recording technique of the glass microelectrode. According to the firing characteristics of GABA neurons,the Proto and Arky subtypes were classified.After exerciseinduced fatigue, the highfrequency regular firing activity of Proto neurons in the external globus pallidus decreased significantly(P

exerciseinduced fatigue;basal ganglia; external globus pallidus; γaminobutyric acid neuron; Prototypic pallidal neurons; Arkypallidal neurons; burst