Abstract:
The aim of present study is to investigate the differences in the regulation of Proto and Arky neurons involved in basal ganglia movement by observing the electrophysiological characteristics of the two subtypes of gammaaminobutyric acid neurons after exerciseinduced fatigue.Healthy male Wistar rats (260~300 g) were randomly divided into control group (CG), 1day fatigue group (1FG), 3day fatigue group (3FG) and 7day fatigue group (7FG). The progressive increasing load treadmill program was used to establish a repetitive exhausted exerciseinduced fatigue model. The spontaneous firing activity of neurons in the external globus pallidus was recorded by the in vivo extracorporeal recording technique of the glass microelectrode. According to the firing characteristics of GABA neurons,the Proto and Arky subtypes were classified.After exerciseinduced fatigue, the highfrequency regular firing activity of Proto neurons in the external globus pallidus decreased significantly(P<0 .01), and the activity of neurons weakened. The lowfrequency firing activity of Arky neurons enhanced significantly(P< 0.01), the activity of neurons increased.The burst/10 s, duration and burst index of burst activity of Proto and Arky neurons increased with the accumulation of exerciseinduced fatigue (P<0.01), and the changes of Arky neurons were more obvious than Proto neurons (P<0.01).Two subtypes of GABA neurons in the external globus pallidus participate in the regulation of exerciseinduced fatigue in different firing patterns. The enhancement of burst activity is one of the characteristics of their common firing activity, which may be related to the excessive activation of indirect pathway caused by exerciseinduced fatigue, and also a compensatory performance of neuronal electrical activity when basal ganglia is dysfunctional.