Abstract:
In order to explore the hypolipidemic effect of Polysaccharides in Shangluo Eucommia folium, Kunming mice is taken as experimental animals, and randomly divided them into 6 groups: blank control , model control , positive control , the low dosages (50 mg/kg BW), the middle dosages (100 mg/kg BW) and the high dosages (150 mg/kg BW) group, each group with 15 mice only. The blank control group was given with basic fodder, another 5 groups was fed with high fat fodder. After taking Eucommia ulmoides leaves polysaccharide for 4 weeks, the fat levels in model mice′s blood serum and liver were determined. The extraction of polysaccharide can obviously decrease the TC, TG, LDL-C, Lp-a and Apo B level,atherosclerosis index (AI) and bolted index (R-CRH). TC, TG content in blood serum and liver tissue had also decreased obviously. At the same time, the HDL-C and Apo-A level in blood serum also increased significantly. Under the condition of a high-fat diet, extraction of polysaccharide can reduce serum lipid levels as well as the lipid metabolism in the liver. It also has a good cholesterol-lowering effect, among which the cholesterol-lowering effect on dosages group is best.
