Correlation of the leukocyte telomere DNA lengths in peripheral blood and lung cancer
ZHANG Yi1, WU Yusi1, SONG Ruirui1, WU Ruifeng2, WANG Jianguo3, ZHONG Li1*
(1 College of Life Sciences，Hebei University, 2 Baoding First Central Hospital, 3 Affiliated Hospital of Hebei University，Baoding 071002, Hebei,China)
Abstract:
Lung cancer is the leading cause of cancer death in China, and its incidence rate keeps growing in recent years majorly due to the deteriorating environmental pollution and raising smoking population. Study of the correlation of the lengths of leukocyte telomere DNA in peripheral blood may contribute to the early diagnosis and treatment of lung cancer. In this study, real-time fluorescence quantitative PCR was used to detect the length of leukocyte telomere DNA in peripheral blood from lung cancer patients and healthy controls, and the relationships between lung cancer and telomere DNA length of peripheral blood leukocytes were analyzed. Results showed that telomere lengths of lung cancer group were shorter than the healthy control group (P
KeyWords:
telomere DNA length; small cell lung cancer(SCLC); non-small cell lung cancer(NSCLC); cancer markers; lung cancer staging
