Abstract:
The effects of exercise training and Cynomorium Songaricum Polysaccharide (CSP) on dilatation function of aorta and involved mechanisms in diabetes rats are discussed. Rats were randomly assigned to the following experimental groups: control group, diabetes group, diabetes+exercise group, diabetes+CSP group. At the end of 8 weeks, measure aortic functions, microstructure and ultrastructure. Immunochemical streptavidin-biotin complex staining and western blot were used to test the distribution and expression of endothelial nitricoxide synthase (eNOS), Akt kinases (Akt) and tumor necrosis growth factor α (TNF-α). These results demonstrated that diabetes degradation of endothelial cells and downregulation the expression of Akt and eNOS, upregulation the expression of TNF-α maybe the factors that decreased the dilatation function of aorta, exercise training and CSP intervention restored the dilatation function of aortic artery may by decreased the injure of endothelial cells, upregulation the expression of Akt and eNOS, downregulation of the expression of TNF-α.
