Abstract:
Thyroid hormone (TH) plays a regulatory function mediated by thyroid hormone receptor (TR), a hormone dependent transcription factors, regulating the transcription of target genes with thyroid hormone response elements,and function of TR, and the results of analyzing TR mammals, amphibians and fish interfered by different EDCs, it is conformed that TR can be used as a biological indicators in environmental endocrine effects of pollutants. TR detection technology at present，including protein and mRNA level， were also introduced and analyzed.In future, the molecular mechanisms of interfere of EDCs on the thyroid system should be deeply explored.
