Abstract:
In order to study the modulation and mechanism of nucleus raphe magnus on gastric motility in rat, experiments were made by means of microinjecting drugs into nucleus raphe magnus（NRM）and recording the frequency and amplitude of gastric motility. The results showed that injection of 5-HT into NRM could increase gastric motility, and naloxone could inhibit the effect of 5-HT. In NRM，IL-6 could increase gastric motility. L-Arg could decrease the motility, and eliminate the effect of 5-HT, and reverse the effect of IL-6; Ritanserin could enhance the effect of L-Arg, and abolish it of IL-6. In conclusion, the effect of 5-HT on gastric motility is modulated by endogenous opioid peptides and NO. Additionally, 5-HT2A receptor could also modulate NO function; IL-6 also participates the modulation of NRM in gastric motility, and work together with NO and 5-HT2A receptor.In NRM, 5-HT, IL-6 and NO form a complex mechanism, they cooperated with each other to regulate the gastric motility.
