YAN Weijuan, Lü Jin, JIANG Qisheng *
（General Hospital of the Second Artillery, Chinese People′s Liberation Army, Beijing 100088, China）
Abstract:
The role and mechanism of miR-424 in the tumor development and progression were comprehensivy reviewed.The miR-424 is a specie of small noncoding single-stranded RNAs with approximate 19-25 nucleotides.In Various tumors,miR-424 participates the regulation of signal path ways of target genes,influence of biological effect of tumor cells,and finally affecting development of tumors,through acting on target gene.The effect is similar to oncogenes to promote or repress tumor invasion and metastasis.It is neccessary in the future to investigate the mechanism of miR-424 in tumor development,early diagnosis of tumor and drug screening.
KeyWords:
miR-424; tumor; tumor suppressor gene; invasion and migration
