XIA Hui-yun1*, YAN Xiang-yang2, WANG Wei-na2, SONG Li-fang1
(1 Engineering Research Center of Transportation Materials, Ministry of Education, School of Materials Science and Engineering, Chang′an University, Xi′an 710061, Shaanxi, China; 2 College of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi′an 710062, Shaanxi, China)
Abstract:
Taking p-hydroquinone and p-benzoquinone as the model polyphenols of redox small molecules, their effect on the formation of lysozyme amyloid fibril and the configuration reversal of mature fibrils were investigated, by using fluorescence spectroscopic techniques and transmission electron microscopy.The results indicated that p-benzoquinone played a mainly role in the inhibition formation of lysozyme amyloid fibril and the reversal of mature fiber.Additionally the inhibition effect and the reversal effect were decided not only by the concentration of p-hydroquinone or p-benzoquinone, but also by the incubation time and media pH.These results are very important to provide usful information in treatments of amyloid-related diseases.
KeyWords:
p-hydroquinone; p-benzoquinone; lysozyme amyloid fibril; inhibition; configuration reversal
