From the perspective of spatiotemporal interaction, the evolution characteristics of environmental regulation and ecological resilience in the middle reaches of the Yangtze River urban agglomeration from 2005 to 2020 were analyzed, and the spatial econometric model was used to clarify the impact of environmental regulation on urban ecological resilience. The results show that: 1)The intensity of environmental regulation in urban agglomeration in the middle reaches of the Yangtze River increased from 0.167 in 2005 to 0.903 in 2020, and the ecological resilience increased from 0.227 to 0.747, both systems showed a fluctuating upward trend. The local spatial structure of urban environmental regulation intensity was relatively stable, and its ecological resilience was strongly dependent on the direction of spatial evolution, and presented a certain degree of spatiotemporal competition. 2) There was a significant inverted Ushaped relationship between environmental regulation intensity and urban ecological resilience. Although the implementation of environmental regulation had a positive spillover effect on the surrounding cities, it had a more obvious effect on the improvement of local ecological resilience. 3) Environmental regulation of suburban agglomerations had a positive and direct effect on the improvement of local ecological resilience, and the impact on surrounding areas was different. The environmental regulation of Wuhan urban area showed a negative spatial spillover effect, the indirect effect of the urban agglomeration around Poyang Lake was positive, and the impact of environmental regulation of the urban agglomeration of ChangshaZhuzhouXiangtan on the surrounding area was not significant.

environmental regulation; urban ecological resilience; spatiotemporal interaction; spatial Dubin model; urban agglomeration in the middle reaches of the Yangtze River