Key competences have become an important educational issue in the word．The evidencebased practice provides methodological guidance for linking key competences theory and practice．Promoting key competences of evidencebased practice framework mainly includes the key competences researchers，to carry out the key competences of educators，to accept the key competences of learners and core management; the four principal of key competences development．The four main subjects should be committed to the key competences of evidencebased practice，follow the scientific，effective and sustainable development of evidencebased practice running mechanism and methods because of the chain evidence of key competences generating and to clear the division of labor，cooperate with each other and bridge the tension in the evidencebased practice．

key competences；evidencebased practice framework；quaternary subjects； running mechanism